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First LRRK2 Drug InN Clinical Trials, Company Files Public Offering

San Francisco-based Denali Therapeutics has raised nearly $250 million in its initial public offering, marking the largest biotech IPO of the year. In announcing terms of the IPO -- a major milestone in the life cycle of any company as it first offers stock options publicly, garnering capital for growth and expansion -- Denali shared it is testing a LRRK2 inhibitor drug in a small trial of control volunteers.

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Parkinson's Protein Levels Stable over Year in Early Disease

Today researchers from the Parkinson's Progression Markers Initiative (PPMI) -- a landmark study to find measures of Parkinson's disease sponsored by The Michael J. Fox Foundation (MJFF) -- published the first results looking at protein levels in spinal fluid in a large, longitudinal cohort. They analyzed cerebrospinal fluid (CSF) from 173 people recently diagnosed with Parkinson's and 112 control volunteers collected at baseline (when they joined PPMI) and six- and 12-month follow-up.

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